Margaret was born blind into a poor, mountain family, who were embittered by her affliction. When she was five years old, they made a pilgrimage to the tomb of a holy Franciscan at Castello to pray for a cure. The miracle failing, they abandoned their daughter in the church of Città-di-Castello and returned to their home.
Margaret was passed from family to family until she was adopted by a kindly peasant woman named Grigia, who had a large family of her own. Margaret’s natural sweetness and goodness soon made themselves felt, and she more than repaid the family for their kindness to her. She was an influence for good in any group of children. She stopped their quarrels, heard their catechism, told them stories, taught them Psalms and prayers. Busy neighbors were soon borrowing her to soothe a sick child or to establish peace in the house.
Her reputation for holiness was so great that a community of sisters in the town asked for her to become one of them. Margaret went happily to join them, but, unfortunately, there was little fervor in the house. The little girl who was so prayerful and penitential was a reproach to their lax lives, so Margaret returned to Grigia, who gladly welcomed her home.
Later, Margaret was received as a Dominican Tertiary and clothed with the religious habit. Grigia’s home became the rendezvous site of troubled souls seeking Margaret’s prayers. She said the Office of the Blessed Virgin and the entire Psalter by heart, and her prayers had the effect of restoring peace of mind to the troubled.
Denied earthly sight, Margaret was favored with heavenly visions. “Oh, if you only knew what I have in my heart!” she often said. The mysteries of the rosary, particularly the joyful mysteries, were so vivid to her that her whole person would light up when she described the scene. She was often in ecstasy, and, despite great joys and favors in prayer, she was often called upon to suffer desolation and interior trials of frightening sorts. The devil tormented her severely at times, but she triumphed over these sufferings.
A number of miracles were performed by Blessed Margaret. On one occasion, while she was praying in an upper room, Grigia’s house caught fire, and she called to Margaret to come down. The blessed, however, called to her to throw her cloak on the flames. This she did, and the blaze died out. At another time, she cured a sister who was losing her eyesight.
Beloved by her adopted family and by her neighbors and friends, Margaret died at the early age of 33. From the time of her death, her tomb in the Dominican church was a place of pilgrimage. Her body, even to this day, is incorrupt. More than 200 miracles have been credited to her intercession after her death. She was beatified in 1609. Thus the daughter that nobody wanted is one of the glories of the Church
After her death, the fathers received permission to have her heart opened. In it were three pearls, having holy figures carved upon them. They recalled the saying so often on the lips of Margaret: “If you only knew what I have in my heart!”.